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Detroit Pistons vs Denver Nuggets Odds, Spread, and Totals

The Detroit Pistons will take on the Denver Nuggets at 9 p.m. EST on Tuesday. This would normally be a matchup of two of the best teams in the NBA,…

DETROIT, MICHIGAN - JANUARY 25: Jaden Ivey #23 of the Detroit Pistons drives to the basket against the Sacramento Kings during the second half at Little Caesars Arena on January 25, 2026 in Detroit, Michigan. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Rey Del Rio/Getty Images)
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The Detroit Pistons will take on the Denver Nuggets at 9 p.m. EST on Tuesday. This would normally be a matchup of two of the best teams in the NBA, but the absence of center Nikola Jokić due to injury looms large for the Nuggets in a huge game here. Despite dealing with that malady, and a variety of others, the Nuggets have managed to continue to play good basketball, going 6-2 in their last eight games. The Pistons have also been excellent in their recent games, going 8-2 in their most recent 10 games, setting the stage for a fun Tuesday night matchup.

While many NBA fans wrote the Pistons' early success off as a flash in the pan, it is now clear that they are one of the best teams in the Eastern Conference. Guard Cade Cunningham has been one of the most prolific offensive players in the league, putting up 25.4 points and 9.4 assists per game. The defense ranks second in the NBA in overall rating, trailing only the Oklahoma City Thunder. With both sides of the team playing exceptionally well, the Pistons present a unique challenge for any team they come across, including the Nuggets on Tuesday.

Head coach David Adelman has quietly been putting on a coaching masterclass for Denver. Without Jokic and forwards Aaron Gordon and Christian Braun, he has turned to a crew of career backups to hold down the fort until reinforcements arrive. Somehow, Adelman has not only stayed afloat, but exceeded in a position where most NBA coaches would immediately embark on a losing streak. Forwards Peyton Watson and Tim Hardaway Jr. deserve credit for their shockingly effective scoring contributions that have served as the backbone of Denver's makeshift lineup. A date with the Pistons will show just how far the Nuggets can go while the core of their team watches in street clothes.

Spread

  • Pistons -6.5 (-113)
  • Nuggets +6.5 (+108)

Money line

  • Pistons -223
  • Nuggets +212

Totals

  • Over 216.5 (-104)
  • Under 216.5 (-104)

Note: The above data was collected on Jan. 27, 2026, and may have changed since writing.

  • Despite their elite record, the Pistons are only 23-21 ATS this year.
  • The Pistons are 6-10 ATS as road favorites.
  • The under is 25-18-1 in Detroit's games.
  • The Nuggets are 27-19 ATS this season, one of the best records in the league.
  • The Nuggets are 10-10 ATS when playing at home.
  • The over is 27-19 in Denver's games.

Pistons vs Nuggets Injury Reports

Detroit Pistons

  • Caris LeVert, F - Out.

Denver Nuggets

  • Jamal Murray, G - Questionable.
  • Christian Braun, F - Out.
  • Peyton Watson, F - Questionable.
  • Aaron Gordon, F - Out.
  • Nikola Jokic, C - Out.

Pistons vs Nuggets Prediction and Pick

The Nuggets have been surprisingly good lately, but they should be overwhelmed on Tuesday against a Pistons team that is almost entirely healthy. Detroit's defense should do more than enough to keep Denver's attack in check, which will allow Cunningham to shred what has been a surprisingly poor defense. Take the Pistons to cover.